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Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies

Background: Systemic adenoviral readministration appears to be limited by immunogenicity. Aims: We examined the feasibility of repeated adenovirus mediated gene transfer into the liver via the biliary tract. Methods: Recombinant adenoviruses carrying a reporter lacZ gene were infused retrogradely in...

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Detalhes bibliográficos
Main Authors: Tominaga, K, Kuriyama, S, Yoshiji, H, Deguchi, A, Kita, Y, Funakoshi, F, Masaki, T, Kurokohchi, K, Uchida, N, Tsujimoto, T, Fukui, H
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2004 by Gut 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774146/
https://ncbi.nlm.nih.gov/pubmed/15247187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.013748
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