BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

Background and aims: Mutations in BRAF have been linked with colorectal cancers (CRC) showing high level microsatellite instability (MSI-H). However, the distribution of BRAF mutations in MSI-H cancers remains to be clarified with respect to precursor lesions and the CpG island methylator phenotype...

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Autori principali: Kambara, T, Simms, L A, Whitehall, V L J, Spring, K J, Wynter, C V A, Walsh, M D, Barker, M A, Arnold, S, McGivern, A, Matsubara, N, Tanaka, N, Higuchi, T, Young, J, Jass, J R, Leggett, B A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Copyright 2004 by Gut 2004
Soggetti:
Colorectal Cancer
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774130/
https://ncbi.nlm.nih.gov/pubmed/15247181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.037671
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