Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats

Background and aims: Hepatic concentrations of the powerful vasoconstrictor and fibrogen endothelin 1 (ET-1) and its receptors increase in human and experimental cirrhosis, suggesting a major role for ET-1 in the pathology of chronic liver disease. We investigated whether ET-1 receptor antagonism, a...

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Detalhes bibliográficos
Main Authors: Thirunavukkarasu, C, Yang, Y, Subbotin, V M, Harvey, S A K, Fung, J, Gandhi, C R
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2004 by Gut 2004
Assuntos:
Liver
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774118/
https://ncbi.nlm.nih.gov/pubmed/15194653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.026534
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