An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo

Background and aims: Interleukin-12 (IL-12), a p35/p40 heterodimer, plays a pivotal role in the immune response in Crohn’s disease (CD). Since IL-12 p40 dimers act as IL-12 antagonists, we assayed p40 dimer proteins to modulate chronic intestinal inflammation. Methods: We generated a fusion protein...

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Main Authors: Stallmach, A, Marth, T, Weiß, B, Wittig, B M, Hombach, A, Schmidt, C, Neurath, M, Zeitz, M, Zeuzem, S, Abken, H
格式: Artigo
語言:Inglês
出版: Copyright 2004 by Gut 2004
主題:
Inflammatory Bowel Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773960/
https://ncbi.nlm.nih.gov/pubmed/14960512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.020107
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