Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse

Background and aims: Substance P (SP) release from sensory nerves induces neurogenic inflammation. Neutral endopeptidase (NEP) degrades SP, thereby limiting its proinflammatory effects. Intestinal inflammation following Trichinella spiralis infection markedly downregulates NEP, resulting in diminish...

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Main Authors: Barbara, G, De Giorgio, R, Stanghellini, V, Corinaldesi, R, Cremon, C, Gerard, N, Gerard, C, Grady, E F, Bunnett, N W, Blennerhassett, P A, Collins, S M
Format: Artigo
Jezik:Inglês
Izdano: Copyright 2003 by Gut 2003
Teme:
Inflammation and Inflammatory Bowel Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773836/
https://ncbi.nlm.nih.gov/pubmed/12970139
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