Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer

Background and aims: Chromosomal instability is one of the most consistent markers of sporadic colorectal cancer in humans. There is growing evidence that telomere shortening is one of the mechanisms leading to chromosomal instability and cancer initiation. Methods: To test this hypothesis, the telo...

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Главные авторы: Plentz, R R, Wiemann, S U, Flemming, P, Meier, P N, Kubicka, S, Kreipe, H, Manns, M P, Rudolph, K L
Формат: Artigo
Язык:Inglês
Опубликовано: Copyright 2003 by Gut 2003
Предметы:
Cancer
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773793/
https://ncbi.nlm.nih.gov/pubmed/12912862
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