Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes

Background: Familial adenomatous polyposis (FAP) is characterised by variable phenotypic expression. Part of this is attributable to a relationship between APC genotype and phenotype but there remains significant intrafamilial variation. In the Min mouse model of FAP, differences in the severity of...

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Main Authors: Crabtree, M D, Tomlinson, I P M, Hodgson, S V, Neale, K, Phillips, R K S, Houlston, R S
Formato: Artigo
Idioma:Inglês
Publicado: Copyright 2002 by Gut 2002
Assuntos:
Colorectal Cancer
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773342/
https://ncbi.nlm.nih.gov/pubmed/12171967
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