Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders

Background and aims: Sildenafil blocks phosphodiesterase type 5 which degrades nitric oxide (NO) stimulated 3`5`-cyclic monophosphate (cGMP), thereby relaxing smooth muscle cells in various organs. We used sildenafil as a tool to investigate the role of the NO-cGMP pathway in the oesophagus of healt...

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Main Authors: Eherer, A J, Schwetz, I, Hammer, H F, Petnehazy, T, Scheidl, S J, Weber, K, Krejs, G J
格式: Artigo
語言:Inglês
出版: Copyright 2002 by Gut 2002
主題:
Oesophagus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773249/
https://ncbi.nlm.nih.gov/pubmed/12010875
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