Control of transient lower oesophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in patients with gastro-oesophageal reflux disease

Background and aims: Transient lower oesophageal sphincter relaxations (TLOSRs) are the major cause of gastro-oesophageal reflux in normal subjects and in most patients with reflux disease. The gamma aminobutyric acid (GABA) receptor type B agonist, baclofen, is a potent inhibitor of TLOSRs in norma...

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Hauptverfasser: Zhang, Q, Lehmann, A, Rigda, R, Dent, J, Holloway, R H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Copyright 2002 by Gut 2002
Schlagworte:
Gastro-Oesophageal Reflux
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773078/
https://ncbi.nlm.nih.gov/pubmed/11772961
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