Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes

The antitumor antibiotic sparsomycin is a universal and potent inhibitor of peptide bond formation and selectively acts on several human tumors. It binds to the ribosome strongly, at an unknown site, in the presence of an N-blocked donor tRNA substrate, which it stabilizes on the ribosome. Its site...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Porse, Bo T., Kirillov, Stanislav V., Awayez, Mariana J., Ottenheijm, Harry C. J., Garrett, Roger A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17722/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430885/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.16.9003
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