A new delivery system for 5-fluorouracil using prodrug and converting enzyme

Aims: To evaluate a new delivery system of 5-fluorouracil (5-FU) using 5-fluorocytosine (5-FC) as a prodrug and cytosine deaminase induced in vitro and in vivo. Methods: Fibroblastic cells from rabbit Tenon's capsule were cultured. The cells were exposed to 5-FU and 5-FC with or without cytosin...

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Autores principales: Akimoto, M, Miyahara, T, Arai, J, Akimoto, A, Hamada, H, Yoshida, Y, Yoshimura, N
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright 2002 British Journal of Ophthalmology 2002
Materias:
Laboratory Science
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1771128/
https://ncbi.nlm.nih.gov/pubmed/11973258
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