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An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

Four macrocyclic cystine-knot peptides of 29–31 residues, kalata, circulin A and B (CirA and CirB), and cyclopsychotride, have been isolated from coffee plants but have undetermined physiological functions. These macrocycles and 10 of their analogs prepared by chemical synthesis were tested against...

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Main Authors: Tam, James P., Lu, Yi-An, Yang, Jin-Long, Chiu, Kou-Wei
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC17707/
https://ncbi.nlm.nih.gov/pubmed/10430870
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