A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins.

A second cluster of genes encoding the E1 alpha, E1 beta, and E2 subunits of branched-chain alpha-keto acid dehydrogenase (BCDH), bkdFGH, has been cloned and characterized from Streptomyces avermitilis, the soil microorganism which produces anthelmintic avermectins. Open reading frame 1 (ORF1) (bkdF...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Denoya, C D, Fedechko, R W, Hafner, E W, McArthur, H A, Morgenstern, M R, Skinner, D D, Stutzman-Engwall, K, Wax, R G, Wernau, W C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC177055/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7768860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.177.12.3504-3511.1995
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