Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin

The fruit fly Drosophila melanogaster was used to examine the mode of action of the novel insecticide and acaricide nodulisporic acid. Flies resistant to nodulisporic acid were selected by stepwise increasing the dose of drug in the culture media. The resistant strain, glc(1), is at least 20-fold re...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kane, Nanci S., Hirschberg, Birgit, Qian, Su, Hunt, David, Thomas, Brande, Brochu, Richard, Ludmerer, Steven W., Zheng, Yingcong, Smith, McHardy, Arena, Joseph P., Cohen, Charles J., Schmatz, Dennis, Warmke, Jeffrey, Cully, Doris F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11095718/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.240464697
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