Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP

Objective: To investigate matrix metalloproteinases (MMP-2 and MMP-9) in heart failure caused by ischaemic and idiopathic dilated cardiomyopathy, and the impact of angiotensin converting enzyme (ACE) inhibition on MMP. Design and main outcome measures: MMP were extracted from myocardium of patients...

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Detalhes bibliográficos
Main Authors: Reinhardt, D, Sigusch, H H, Henβe, J, Tyagi, S C, Körfer, R, Figulla, H R
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2002 by Heart 2002
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1767416/
https://ncbi.nlm.nih.gov/pubmed/12381651
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