Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

A Streptomyces clavuligerus mutant disrupted in cas2, encoding the clavaminate synthase (CAS2) isoenzyme, was constructed by a gene replacement procedure. The resulting cas2 mutant showed no clavulanic acid production when grown in starch-asparagine medium. However, in soy medium, the cas2 mutant di...

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Veröffentlicht in:	J Bacteriol
Hauptverfasser:	Paradkar, A S, Jensen, S E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176738/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7868606/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.177.5.1307-1314.1995
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