Randomized Dose-Ranging Controlled Trial of AQ-13, a Candidate Antimalarial, and Chloroquine in Healthy Volunteers

OBJECTIVES: To determine: (1) the pharmacokinetics and safety of an investigational aminoquinoline active against multidrug–resistant malaria parasites (AQ-13), including its effects on the QT interval, and (2) whether it has pharmacokinetic and safety profiles similar to chloroquine (CQ) in humans....

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Detalhes bibliográficos
Main Authors: Mzayek, Fawaz, Deng, Haiyan, Mather, Frances J, Wasilevich, Elizabeth C, Liu, Huayin, Hadi, Christiane M, Chansolme, David H, Murphy, Holly A, Melek, Bekir H, Tenaglia, Alan N, Mushatt, David M, Dreisbach, Albert W, Lertora, Juan J. L, Krogstad, Donald J
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764434/
https://ncbi.nlm.nih.gov/pubmed/17213921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pctr.0020006
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