Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: A biomarker for the early detection of cancer

BACKGROUND: Somatic mutations of mitochondrial DNA (mtDNA) are common in many human cancers. We have described an oligonucleotide microarray ("MitoChip") for rapid sequencing of the entire mitochondrial genome (Zhou et al, J Mol Diagn 2006), facilitating the analysis of mtDNA mutations in...

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Detalhes bibliográficos
Main Authors: Sui, Guoping, Zhou, Shaoyu, Wang, Jean, Canto, Marcia, Lee, Edward E, Eshleman, James R, Montgomery, Elizabeth A, Sidransky, David, Califano, Joseph A, Maitra, Anirban
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764424/
https://ncbi.nlm.nih.gov/pubmed/17166268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-5-73
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