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Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1

Megakaryocytes lacking transcription factor GATA-1 fail to complete maturation in vivo and hyperproliferate. To define how GATA-1 regulates megakaryocyte cell growth we searched for mRNA transcripts expressed in primary wild-type, but not GATA-1(−), megakaryocytes. One differentially expressed trans...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Vyas, Paresh, Norris, F. Anderson, Joseph, Raji, Majerus, Philip W., Orkin, Stuart H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17638/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087841/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250476397
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