Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.

The molecular mechanism of plasmid-mediated resistance to fosfomycin is described. The antibiotic was inactivated intracellularly and remained inside the cells. Modification was also obtained from cell extracts and was not energy dependent. The modifying enzyme seems to have sulfhydryl groups in its...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Llaneza, J, Villar, C J, Salas, J A, Suarez, J E, Mendoza, M C, Hardisson, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176334/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3899003/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.28.1.163
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