Tay-Sachs disease: high gene frequency in a non-Jewish population.

A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews.

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Bibliographic Details
Main Authors: Kelly, T E, Chase, G A, Kaback, M M, Kumor, K, McKusick, V A
Format: Artigo
Language:Inglês
Published: 1975
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762873/
https://ncbi.nlm.nih.gov/pubmed/803011
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