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Alternative Complement Pathway in the Pathogenesis of Disease Mediated by Anti-Neutrophil Cytoplasmic Autoantibodies

Clinical and experimental data indicate that anti-neutrophil cytoplasmic autoantibodies (ANCAs) cause glomerulonephritis and vasculitis. Here we report the first evidence that complement is an important mediator of ANCA disease. Transfer of anti-myeloperoxidase (MPO) IgG into wild-type mice or anti-...

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Main Authors: Xiao, Hong, Schreiber, Adrian, Heeringa, Peter, Falk, Ronald J., Jennette, J. Charles
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762697/
https://ncbi.nlm.nih.gov/pubmed/17200182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060573
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