Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells.

We examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with herpes simplex virus type 1 and type 2. DHPG inhibited virus DNA synthesis in a dose-dependent fashion. This inhibition was not due to the lack of de...

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Autores principales: Cheng, Y C, Grill, S P, Dutschman, G E, Frank, K B, Chiou, J F, Bastow, K F, Nakayama, K
Formato: Artigo
Lenguaje:Inglês
Publicado: 1984
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC176152/
https://ncbi.nlm.nih.gov/pubmed/6095751
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