Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells.

We examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with herpes simplex virus type 1 and type 2. DHPG inhibited virus DNA synthesis in a dose-dependent fashion. This inhibition was not due to the lack of de...

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Bibliografski detalji

Izdano u:	Antimicrob Agents Chemother
Glavni autori:	Cheng, Y C, Grill, S P, Dutschman, G E, Frank, K B, Chiou, J F, Bastow, K F, Nakayama, K
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1984
Teme:	Research Article
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6095751/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.26.3.283
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