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Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist
A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric γ-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 μM GABA (IC(50)=41.6 nM, wild-type RDL(ac)...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1760657/ https://ncbi.nlm.nih.gov/pubmed/10455279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702663 |
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