Pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys of (R,S)-9-[4-hydroxy-2-(hydroxymethyl) butyl]guanine, an anti-varicella-zoster virus drug.

The acyclic guanosine analog (R,S)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine, (+/-)2HM-HBG, is an effective inhibitor of herpes simplex virus and varicella-zoster virus infections in vitro. This report is concerned with the pharmacokinetic evaluation of the drug in rats and monkeys and its antivir...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Lake-Bakaar, D M, Abele, G, Lindborg, B, Soike, K F, Datema, R
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1988
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176023/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2854453/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.12.1807
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