Rb is critical in a mammalian tissue stem cell population

The inactivation of the retinoblastoma (Rb) tumor suppressor gene in mice results in ectopic proliferation, apoptosis, and impaired differentiation in extraembryonic, neural, and erythroid lineages, culminating in fetal death by embryonic day 15.5 (E15.5). Here we show that the specific loss of Rb i...

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Detalhes bibliográficos
Main Authors: Wenzel, Pamela L., Wu, Lizhao, de Bruin, Alain, Chong, Jean-Leon, Chen, Wen-Yi, Dureska, Geoffrey, Sites, Emily, Pan, Tony, Sharma, Ashish, Huang, Kun, Ridgway, Randall, Mosaliganti, Kishore, Sharp, Richard, Machiraju, Raghu, Saltz, Joel, Yamamoto, Hideyuki, Cross, James C., Robinson, Michael L., Leone, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1759903/
https://ncbi.nlm.nih.gov/pubmed/17210791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1485307
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