High-level resistance to trimethoprim in Shigella sonnei associated with plasmid-encoded dihydrofolate reductase type I.

By DNA hybridization, the gene encoding dihydrofolate reductase type I was found in 58 of 59 highly trimethoprim-resistant clinical isolates of Shigella sonnei obtained from 1981 through 1987 in Madrid, Spain. No strain harbored the type II gene. In selected strains, the type I gene was demonstrated...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Delgado, R, Otero, J R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175929/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3056243/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.10.1598
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