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Effect of NaCl and nafcillin on penicillin-binding protein 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus.

Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus is enhanced by 2 to 5% NaCl in the medium and by selection with beta-lactam antibiotics. Resistance is associated with production of a penicillin-binding protein (PBP), PBP 2a, with low affinity for binding beta-l...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Chambers, H F, Hackbarth, C J
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1987
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175839/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3439805/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.12.1982
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