Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution.

Azithromycin (CP-62,993), a new acid-stable 15-membered-ring macrolide, was well absorbed following oral administration in mice, rats, dogs, and cynomolgus monkeys. This compound exhibited a uniformly long elimination half-life and was distributed exceptionally well into all tissues. This extravascu...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Girard, A E, Girard, D, English, A R, Gootz, T D, Cimochowski, C R, Faiella, J A, Haskell, S L, Retsema, J A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175833/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2830841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.12.1948
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