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Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation

Phosphatidylinositol-3-phosphate (PtdIns-3-P) is considered as a lipid constitutively present on endosomes; it does not seem to have a dynamic role in signalling. In contrast, phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P(3)) plays a crucial role in different signalling pathways including...

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Udgivet i:EMBO J
Principais autores: Maffucci, Tania, Brancaccio, Anna, Piccolo, Enza, Stein, Robert C., Falasca, Marco
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175792/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12912916/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg402
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