Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases

Suicide gene therapy systems such as the herpes simplex thymidine kinase/ganciclovir system (TK/GCV) may kill cancer cells by apoptosis through as yet undefined mechanisms. Here we show that TK/GCV treatment induces p53 accumulation and increases cell surface expression of CD95 and tumor necrosis fa...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Beltinger, Christian, Fulda, Simone, Kammertoens, Thomas, Meyer, Eric, Uckert, Wolfgang, Debatin, Klaus-Michael
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1999
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411938/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8699
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