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CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-γ

CD4(+) T cells can eliminate tumor cells in vivo in the absence of CD8(+) T cells. We have CD4(+) T cells specific for a MHC class II-restricted, tumor-specific peptide derived from a mutant ribosomal protein expressed by the UV light-induced tumor 6132A-PRO. By using neutralizing mAb specific for m...

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Detalhes bibliográficos
Main Authors: Mumberg, Dominik, Monach, Paul A., Wanderling, Sherry, Philip, Mary, Toledano, Alicia Y., Schreiber, Robert D., Schreiber, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17568/
https://ncbi.nlm.nih.gov/pubmed/10411927
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