Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses

CTLA-4-deficient mice develop a fatal lymphoproliferative disorder, characterized by polyclonal expansion of peripheral lymphocytes. To examine the effect of restricting the CD4(+) TCR repertoire on the phenotype of CTLA-4-deficient mice and to assess the influence of CTLA-4 on peptide-specific CD4(...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Chambers, Cynthia A., Kuhns, Michael S., Allison, James P.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1999
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17563/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411922/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8603
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