Clostridium septicum alpha-toxin is proteolytically activated by furin.

Clostridium septicum alpha-toxin is secreted as an inactive 46,450-Da protoxin. The protoxin is activated by proteolytic cleavage near the C terminus, which eventually causes the release of a 45-amino-acid fragment. Proteoytic activation and loss of the propeptide allow alpha-toxin to oligomerize an...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Gordon, V M, Benz, R, Fujii, K, Leppla, S H, Tweten, R K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175594/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9317018/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.10.4130-4134.1997
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