Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNFα and IL18 but not CXCL12

Background: Tumour necrosis α (TNFα) blocking agents lead to pronounced clinical effects and reduced synovial infiltrate in rheumatoid arthritis. Laboratory and clinical studies suggest that TNFα independent pathways play a role in the disease. Objectives: To evaluate the immunopathological effects...

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Bibliographic Details
Main Authors: van Oosterhout, M, Levarht, E, Sont, J, Huizinga, T, Toes, R, van Laar, J M
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Extended Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1755439/
https://ncbi.nlm.nih.gov/pubmed/15769913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2004.024927
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