Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor α, interleukin 1, and receptor activator of nuclear factor κB ligand (RANKL) regulate osteoclasts

Background: Osteoclasts, specialised bone resorbing cells regulated by RANKL and M-CSF, are implicated in rheumatoid joint erosion. Lymphocyte-monocyte interactions activate bone resorption, this being attributed to tumour necrosis factor α (TNFα) and interleukin 1 ß (IL1ß) enhanced osteoblast expre...

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Bibliographic Details
Main Authors: O', G, Ireland, D, Bord, S, Compston, J
Format: Artigo
Language:Inglês
Published: 2004
Subjects:
Extended Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1754946/
https://ncbi.nlm.nih.gov/pubmed/15020327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2003.008458
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