Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain.

Clostridium difficile causes pseudomembranous colitis through the action of Rho-modifying proteins, toxins A and B. Antibodies directed against C. difficile toxin A prevent or limit C. difficile-induced colitis. We engineered plasmid pETR14, containing the hlyB and hlyD genes of the Escherichia coli...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Ryan, E T, Butterton, J R, Smith, R N, Carroll, P A, Crean, T I, Calderwood, S B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175412/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9199470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.7.2941-2949.1997
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