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Leflunomide: mode of action in the treatment of rheumatoid arthritis
Leflunomide is a selective inhibitor of de novo pyrimidine synthesis. In phase II and III clinical trials of active rheumatoid arthritis, leflunomide was shown to improve primary and secondary outcome measures with a satisfactory safety profile. The active metabolite of leflunomide, A77 1726, at low...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1753034/ https://ncbi.nlm.nih.gov/pubmed/11053058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.59.11.841 |
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