Immunogenicity and protection in small-animal models with controlled-release tetanus toxoid microparticles as a single-dose vaccine.

Tetanus toxoid (TT) was encapsulated in microparticles prepared from polylactide-co-glycolide polymers by a solvent-evaporation technique. Combinations of small- and large-sized microparticles with controlled-release characteristics were used to immunize Sprague-Dawley rats, and the antibody respons...

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Autors principals: Singh, M, Li, X M, Wang, H, McGee, J P, Zamb, T, Koff, W, Wang, C Y, O'Hagan, D T
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC175204/
https://ncbi.nlm.nih.gov/pubmed/9125552
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