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H-89 inhibits transient outward and inward rectifier potassium currents in isolated rat ventricular myocytes

1. Voltage clamp was used to investigate the effects of N-[2-p-bromo-cinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), a potent inhibitor of PKA, on transient outward K(+) current (I(to)) and inward rectifying K(+) current (I(K1)) in rat cardiac muscle. 2. Initial experiments, performed using d...

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Detalhes bibliográficos
Main Authors: Pearman, Charles, Kent, William, Bracken, Nicolas, Hussain, Munir
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1752020/
https://ncbi.nlm.nih.gov/pubmed/16799649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706810
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