Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFα in macrophages: role of TLRs in synergy between the two

1. Gram-negative and Gram-positive bacteria are sensed by Toll-like receptor (TLR)4 and TLR2, respectively. TLR4 recruits MyD88 and TRIF, whereas TLR2 recruits MyD88 without TRIF. NOSII and TNFα are central genes in innate immunity and are thought to be differentially regulated by the MyD88 versus T...

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Main Authors: Paul-Clark, Mark J, Mc Master, Shaun K, Belcher, Elizabeth, Sorrentino, Rosalinda, Anandarajah, Jasmine, Fleet, Mark, Sriskandan, Shiranee, Mitchell, Jane A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1752017/
https://ncbi.nlm.nih.gov/pubmed/16783405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706815
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