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Electrostatic free energy landscapes for nucleic acid helix assembly

Metal ions are crucial for nucleic acid folding. From the free energy landscapes, we investigate the detailed mechanism for ion-induced collapse for a paradigm system: loop-tethered short DNA helices. We find that Na(+) and Mg(2+) play distinctive roles in helix–helix assembly. High [Na(+)] (>0.3...

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Autores principales: Tan, Zhi-Jie, Chen, Shi-Jie
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751542/
https://ncbi.nlm.nih.gov/pubmed/17145719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl810
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