A small molecule, orally active, α(4)β(1)/α(4)β(7) dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats

1. α(4)β(1) and α(4)β(7) integrins are preferentially expressed on eosinophils and mononuclear leukocytes and play critical roles in their recruitment to inflammatory sites. We investigated the effects of TR14035, a small molecule, α(4)β(1)/α(4)β(7) dual antagonist, in a rat model of allergic asthma...

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Detalhes bibliográficos
Main Authors: Cortijo, Julio, Sanz, María-Jesús, Iranzo, Arantxa, Montesinos, José Luis, Nabah, Yafa Naim Abu, Alfón, José, Gómez, Luis A, Merlos, Manuel, Morcillo, Esteban J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751336/
https://ncbi.nlm.nih.gov/pubmed/16432509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706658
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