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Ketamine impairs excitability in superficial dorsal horn neurones by blocking sodium and voltage-gated potassium currents

1. Ketamine shows, besides its general anaesthetic effect, a potent analgesic effect after spinal administration. We investigated the local anaesthetic-like action of ketamine and its enantiomers in Na(+) and K(+) channels and their functional consequences in dorsal horn neurones of laminae I–III, w...

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Detalhes bibliográficos
Main Authors: Schnoebel, Rose, Wolff, Matthias, Peters, Saskia C, Bräu, Michael E, Scholz, Andreas, Hempelmann, Gunter, Olschewski, Horst, Olschewski, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751212/
https://ncbi.nlm.nih.gov/pubmed/16151436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706385
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