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Systemic hypothermia increases PAI-1 expression and accelerates microvascular thrombus formation in endotoxemic mice

INTRODUCTION: Hypothermia during sepsis significantly impairs patient outcome in clinical practice. Severe sepsis is closely linked to activation of the coagulation system, resulting in microthrombosis and subsequent organ failure. Herein, we studied whether systemic hypothermia accelerates microvas...

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Detalhes bibliográficos
Main Authors: Lindenblatt, Nicole, Menger, Michael D, Klar, Ernst, Vollmar, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751084/
https://ncbi.nlm.nih.gov/pubmed/17062126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc5074
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