Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.

Trimetrexate and BW301U (piritrexim isethionate), lipid-soluble inhibitors of dihydrofolate reductase, are potent inhibitors of the growth of Pneumocystis carinii in culture with WI-38 cells. Inhibition was observed with 0.1 microgram of trimetrexate or BW301U per ml. Trimethoprim is ineffective at...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Queener, S F, Bartlett, M S, Jay, M A, Durkin, M M, Smith, J W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2445281/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.9.1323
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