Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance.

An in vitro pharmacokinetic model was used to study the comparative antibacterial activities of multiple-dose regimens of enoxacin and netilmicin. Strains of Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus were exposed to changing drug concentrations, mimic...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Blaser, J, Stone, B B, Groner, M C, Zinner, S H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174871/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3116917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.7.1054
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