Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B.

Intercalation of amphotericin B into liposomes at a 10 mol% drug/lipid ratio decreased its cytotoxicity by 3- to 90-fold in cultured murine cells and reduced its lethality by 2- to 8-fold in a median lethal dose (LD50) test in mice when compared with the commercial deoxycholate-solubilized drug (LD5...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Szoka, F C, Milholland, D, Barza, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174744/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3579259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.3.421
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