Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture.

The activity and mode of action of the new nucleoside analog (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) against varicella-zoster virus (VZV) were determined. In cell culture, replication of different strains of VZV was inhibited to 50% by 0.4 to 0.7 microM 2HM-HBG, while 685 microM w...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Abele, G, Karlström, A, Harmenberg, J, Shigeta, S, Larsson, A, Lindborg, B, Wahren, B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3032092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.1.76
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