Synthesis of hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits: potential for use in a broad-spectrum vaccine.

Three variants of the cholera toxin B subunit (CTB) were generated by site-specific mutagenesis in which regions of the mature protein were altered to the composition found at the corresponding positions of the closely related B subunit of the heat-labile enterotoxin of enterotoxigenic Escherichia c...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Lebens, M, Shahabi, V, Bäckström, M, Houze, T, Lindblad, N, Holmgren, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174048/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675319/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.6.2144-2150.1996
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